In meningococcal sepsis, plasminogen-activator-inhibitor-1 (PAI-1) levels are increased and result in inhibited fibrinolysis and impaired anticoagulant mechanism, since PAI-1 neutralizes activated protein C [2], leading to severe disseminated intravascular coagulation (DIC). Here, SERPINE1 is linked to Disseminated intravascular coagulation.