It has been shown that high doses of sodium salicylate can have positive effects on glucose regulation, and insulin sensitivity in T2DM [50–52]; however, there is a strong level of toxicity involved with high levels of sodium salicylate intake [53] and the specific effects of sodium salicylate on NPY/AgRP neurons in the hypothalamus has not been studied. This evidence concerns the gene INS and type 2 diabetes mellitus.