Both population-based cohorts include large numbers of healthy volunteers [subjects with eGFR(crea) >60 ml/min/1.73m2: SHIP-1 n = 2814 (91.3%); SHIP-Trend n = 3829 (93.7%)], thus confirming that the above-mentioned association also exists outside the area of overt renal disease. This evidence concerns the gene INPP5D and kidney disorder.