The exclusion of subjects with hypertension or diabetes mellitus type 2 eliminated the associations between serum creatinine or the eGFR(crea) and serum Ang-2 concentrations but did not substantially affect the findings for serum cystatin C and eGFR(cys) (Figs 2 and 3, Table 2). This evidence concerns the gene CST3 and type 2 diabetes mellitus.