VEGFA and neoplasm: The role of MC mediators in tumor growth is very complex and reaches from promoting angiogenesis through VEGF, FGF-2, tryptase and chymase, generating immunosuppression by releasing Il-10, histamine and TNF-alpha, promoting tumor invasiveness by dissolving extracellular matrix through matrix metalloproteases, to promoting inflammation and inhibiting tumor cell growth and tumor cell apoptosis by releasing cytokines such as Interferon-alpha, TNF-alpha, Il-1, Il-4, Il-6.[2]