The protein levels of amyloid precursor protein (APP) is increased in AD due to the dysregulated RNA processing with unspliced RNA species including myc box dependent-interacting protein 1, clusterin and presenilin-1 [10].Several signaling pathways such as MAPK [11], PI3K/AKT [12], NF-κB and Wnt pathways [13] might be involved in Aβ-induced neuronal apoptosis. This evidence concerns the gene AKT1 and Alzheimer disease.