MiR-493 was also shown to be significantly upregulated in ATCH-PCs, and the MiRBase database predicts that miRNA-493 can target RUNX2 and LGALS3 mRNA.[31] The LGALS-3 gene encodes the adhesion protein galectin-3, which is a downstream target of the transcription factor RUNX2 and regulates pituitary tumor cell proliferation and apoptosis. This evidence concerns the gene RUNX2 and pituitary tumor.