Numerous causes for low magnesium levels in diabetics can be listed including diets low in magnesium, osmotic diuresis that leads to high renal excretion of magnesium, insensitivity to insulin that affects intracellular magnesium transport and causes increased loss of extracellular magnesium, usage of loop and thiazide diuretics that promote magnesium wasting, diabetic autonomic neuropathies, and reduced tubular reabsorption due to insulin resistance. Here, INS is linked to diabetic autonomic neuropathy.