Further upregulation and downreguation of FGFR1 signaling revealed that FGFR1 is linked to a mechanism triggering MAPK/ERK phosphorylation and translocation from cytoplasm to nucleus, which appears to be necessary for brachyury activation and is also important for facilitating EMT, cell/tumor growth and invasion of lung cancer. The gene discussed is FGFR1; the disease is lung cancer.