FGFR1 and neoplasm: To test the biological function of FGFR1/MAPK in brachyury-driven lung cancer cell/tumor growth and invasion, we examined the response of lung cancer cell lines with differential brachyury expressions to PD 173074 and PD 184352 and found that cell lines H226 and H460 with endogenously higher brachyury expression were more susceptible to treatment by PD 173074 or PD 184352 (Figure 5A).