We found that the phosphorylation of AKT and STAT3 was robustly inhibited by KIAA0247 overexpression in glioma cells, in contrast, knockdown of KIAA0247 could enhance phosphorylation of AKT and STAT3, indicating that KIAA0247 can suppress cell proliferation, angiogenesis and promote apoptosis in part through AKT and STAT3 signaling pathways. Here, SUSD6 is linked to central nervous system cancer.