In addition, AKT and STAT3 has been confirmed to be involved in the regulation of downstream factors including PCNA [33], Bcl2 [34, 35], CyclinD1 [33, 35] and VEGF [36, 37], which are related to tumor proliferation, apoptosis and angiogenesis in glioma cells. This evidence concerns the gene STAT3 and central nervous system cancer.