PTTG1 and breast cancer: The transwell assay with or without matrigel suggested miR-146a-3p overexpression significantly inhibited BC cell migration and invasion, while PTTG1 overexpression promoted BC cell migration and invasion, miR-146a-3p and PTTG1 co-overexpression restored BC cell migration and invasion abilities compared to miR-146a-3p overexpression (Figure 6A and 6B).