COTL1 and non-small cell lung carcinoma: In addition, the mRNA and protein levels of COTL1 were also greatly upregulated in three different NSCLC cell lines (e.g. A549, HCC827 and SPC-A1 cells), when compared with that of non-tumorigenic bronchial epithelium cell line BEAS-2B cells (Figure 4E–4F, P < 0.05).