Importantly, we also found that GATA3 transcriptional actives miR-506-3p expression, and the long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) exerts oncogenic function in NSCLC by competitively ‘sponging’ miRNA-506. The gene discussed is UCA1; the disease is non-small cell lung carcinoma.