PTX3 and graft versus host disease: Remarkably, the median PTX3 level at disease onset was 33.08 ng/ml (range = 5.15; 847.44) in the grade II-IV acute GvHD group, a value significantly higher than that observed in patients who developed mild acute GvHD, whose median PTX3 level was 15.69 (range = 7.27; 80.57, p = 0.0165, Figure 4A).