In this study, we investigated KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in NSCLC patient tumor tissues by immunohistochemistry (IHC) and analyzed the correlation between KIR 2D (L1, L3, L4, S4), KIR 3DL1 and clinical pathological characteristics. The gene discussed is KIR3DL1; the disease is non-small cell lung carcinoma.