In this study, we investigated KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in NSCLC tumor tissues and analyzed the correlation between KIR 2D (L1, L3, L4, S4), KIR 3DL1 and clinical pathological characteristics. This evidence concerns the gene KIR3DL1 and non-small cell lung carcinoma.