Among 6,279 subjects from the general population in Norway with a median follow-up of 13.5 years (3,174 women), Vik et al., reported a significant inverse relationship between serum OPG levels and breast cancer risk (HR tertile 3 vs. tertile 1 = 0.24; 95%CI 0.10–0.61; P – trend = 0.002) [21]. The gene discussed is TNFRSF11B; the disease is breast cancer.