The ability of some IVE-TB antigens to induce Th2 related IL-13 response might be in line with our recent findings on Mtb specific HLA-E restricted CD8+ T-cells which had a ‘Th2-like’ profile, while still being able to actively lyse Mtb infected cells and inhibit intracellular Mtb outgrowth67. The gene discussed is HLA-E; the disease is tuberculosis.