FOXO1 and colonic neoplasm: In rhabdomyosarcoma cells, the overexpression of FHL2 induced apoptosis.30 In tongue squamous cancer cells, however, the expression of FHL2 contributed to growth, proliferation, invasiveness and metastasis.31 In prostate cancer cells, the expression of FHL2 alone also inhibited FOXO1-induced apoptosis.32 In gastric and colon cancer cells, the suppression of FHL2 inhibited the serum-dependent, anchorage-dependent and anchorage-independent cell growth.22 Most of the previous studies on rgw overexpression of FHL2 found that it enhanced cell proliferation and migration.