Four-and-a-half LIM domains protein 2 (FHL2) is the second member of a small family of five proteins with four-and-a-half LIM domains.21, 22 This domain is a specialized double zinc finger (ZF) protein motif with versatile cellular roles as regulators of gene expression, cyto-architecture, cell adhesion, cell motility and signal transduction.23, 24, 25 Accumulated evidence indicate that FHL2 functions as an oncogene in some type of cancers.22, 26, 27 In a previous study, Shi et al.28 reported that FOXK1 interacts with FHL2 in the myogenic progenitor cell. The gene discussed is FOXK1; the disease is cancer.