FOXK1 and colorectal carcinoma: FOXK1 is a transcription factor that belongs to the forkhead family, which consists of the winged-helix DNA-binding domain and the N-terminal and C-terminal transcriptional domains.16, 17, 20 Wang et al.29 reported that the FOXK1 protein levels are elevated in human CRC and positively regulate Wnt/b-catenin by translocating DVL into the nucleus.