Given that IL-1α deficiency did not provide protection from dermatitis or systemic inflammation in Sharpincpdm mice (Fig. 5 and Extended Data Figs 7 and 8), we hypothesized that IL-1β (the other IL-1 cytokine that signals through IL-1R) would be involved in the progression of disease in Sharpincpdm mice. This evidence concerns the gene IL1R1 and dermatitis.