IL1R1 and skin disorder: Given that IL-1α deficiency did not provide protection from dermatitis or systemic inflammation in Sharpincpdm mice (Fig. 5 and Extended Data Figs 7 and 8), we hypothesized that IL-1β (the other IL-1 cytokine that signals through IL-1R) would be involved in the progression of disease in Sharpincpdm mice.