Of note are reports that DGKα and ζ manifest differential effects on TNFα-induced NFκB activation in tumor cells and fibroblasts, with DGKα positively regulating PKCζ-mediated p65/RelA at serine 311 residue (Yanagisawa et al., 2007; Kai et al., 2009), while DGKζ inhibits TNFα-induced NFκB activation via decreasing NFkB phosphorylation at Ser468/536, its nuclear localization, and its association with CBP (Tsuchiya et al., 2015). The gene discussed is DGKZ; the disease is neoplasm.