ESR1 and posterior cortical atrophy: Hypermethylation is one of the best dissected epigenetic alterations in PCa and involves well-known genes that are important in DNA damage repair (GSTP1 and MGMT), apoptosis (DAPK1; RASSF1), hormonal response (androgen receptor-AR, estrogen receptor-ER, and RARβ), inflammatory responses (prostaglandin endoperoxide synthase 2-PTGS2), cell-cycle control (CDKN2A), and metastases (Cadherins, CD44, and tissue inhibitor metallopeptidase (TIMP)) [26].