Another important aspect of preexisting AE36 immunity is the local production of cytokines, such as IFNγ, by activated CD4+/AE36+ cells, which could not only restore tumor cells’ HLA class I loss, but also activate components of innate immune system against tumor cells (e.g. NK cells, eosinophils, macrophages and neutrophils). The gene discussed is CD4; the disease is neoplasm.