It is worth remembering that there are already monoclonal antibodies against IL-17 (secukinumab and ixekizumab), already released for the treatment of rheumatic diseases that have activation of IL-17-axis as a crucial point in its pathogenesis (91), and the newest and attractive tregalizumab a monoclonal antibody that binds to CD4 T cells and induces Treg activation (158). This evidence concerns the gene IL17A and rheumatic disorder.