In experimental models, liver infiltration by Th17 cells showed to be a critical element for NASH initiation and development of fibrosis in wild-type mice, and this infiltration was accompanied by an increase in the production of pro-inflammatory cytokines (IL-6, TNF-α, and TGF-β) (42). The gene discussed is TGFB1; the disease is metabolic dysfunction-associated steatohepatitis.