The NAFLD immune imbalances, in addition to the above, appears to be also associated with deficient synthesis or release of anti-inflammatory and antifibrotic cytokines as IL-10 (58, 61), IL-4 (61, 123), IL-22 (42), and interferon gamma (IFN-γ) (124) that have a protective effect by suppressing the maturation of Th17 cells or counterbalancing the IL-17 effects (42, 61, 125–127). This evidence concerns the gene IL10 and metabolic dysfunction-associated steatotic liver disease.