Lichner et al. (2015) reported that isolated RCC spheres displayed CSC-like properties that were linked to the TGF-β-EMT axis. Additionally, recent research has suggested that EMT can be artificially induced during the culture of the RCC cell lines ACHN and 786-O, enriching their stem cell-like characteristics (Liu and Fan, 2015). Here, TGFB1 is linked to renal cell carcinoma.