By analyzing data in The Cancer Genome Atlas’ Kidney Renal Clear Cell Carcinoma (TCGA KIRC) dataset, Weygant et al. (2015) demonstrated that doublecortin-like kinase 1 (DCLK1) regulates EMT and maintains stemness features; DCLK1 is overexpressed in RCC tumors regardless of disease stage. The gene discussed is DCLK1; the disease is renal cell carcinoma.