SNCA and Parkinson disease: With the dysfunction of multiple neurotransmitters (Gratwicke et al., 2015; Pagonabarraga et al., 2015) and deposition of alpha-synuclein (Braak et al., 2005), network hubs are almost certainly vulnerable in PD (Stam, 2014), and the selective deterioration of these network hubs may account for the distributed abnormalities across the brain in PD (McColgan et al., 2015) with distinct clinical correlations.