BACE1 and Alzheimer disease: However, a reduction of BACE1 protein under a pathological over-expressed BACE1 activity condition, could suggest an important benefit in neuroprotection, remyelination and plasticity (Farah et al., 2011; Piedrahita et al., 2016), supported by the recovery of the cognitive function in the shBACE1miR treated 3xTg-AD mice.