However, this work suggests by the first time that BACE1 is involved in FA composition of PE-derivates (LPE and ePE), and that the shBACE1miR treatment in 3xTg-AD mice restores the levels of lipid subspecies that are altered by the disease in the animal model, preventing pro-inflammatory signaling, which could be associated the reduction of tauopathy and with the learning and memory improvement. This evidence concerns the gene BACE1 and tauopathy.