In agreement with our previous studies, this BACE1 knock-down’s effect could be also related to the reduction of the hyperphosphorylation of tau and recovery of PE-dependent autophagosome formation (Piedrahita et al., 2016); since those processes are progressively affected in the 3xTg-AD mice at 12 and 18 months old (Villamil-Ortiz and Cardona-Gomez, 2015). The gene discussed is BACE1; the disease is Alzheimer disease.