BACE1 and Alzheimer disease: In this study, we present the lipidomic profiles of hippocampal tissue obtained from a commonly used transgenic mouse model of AD (3xTg-AD) treated with RNA interference (RNAi) against BACE1 for 6 and 12 months and compared them with control groups, using mass spectrometry, we detected and analyzed 12 different lipid classes and subclasses, including phospholipids (PLs), sphingolipids, lysophospholipids, plasmalogens, covering over 402 lipid subspecies.