BACE1 and Alzheimer disease: Interestingly, in this work, we demonstrated that BACE1 silencing restored the amount of ePE in the hippocampus of 3xTg-AD mice to the control levels, suggesting that BACE1 silencing may play a role in the regulation of PLA2 activity restoring the homeostasis of this plasmalogen and allowing it to reach effective concentrations for antioxidant activity.