BACE1 and Alzheimer disease: Our findings suggest by the first time that the long-term silencing of BACE1 prevents the learning and memory impairment in 3xTg-AD mice, by restoration of the composition of PE derivates, as LPE and ePE, and the subsequent blocking of the pro-inflammatory activation of cPLA2/AA/COX- 2 pathway in the hippocampus.