BACE1 and Alzheimer disease: In contrast, the lipid profile obtained from the shBACE1miR-treated 3xTg-AD mice showed that the treatment restored the LPE (p < 0.001) and ePE (p < 0.05) content to basal levels (Figures 3A,B), suggesting a regulatory role for BACE1 in the biosynthesis of these particular plasmalogens.