TNF and early-onset autosomal dominant Alzheimer disease: Furthermore, memory impairment in the double-transgenic animal model of Alzheimer's disease is independent of hippocampal neuronal volume, and is completely reversed by inhibiting innate immune cytokines, namely interleukin-1(Ben-Menachem-Zidon et al., 2014), and TNFα (Tweedie et al., 2012).