A selective 5-HT6R antagonist was able to attenuate spontaneous recurrent seizures in the post-SE pilocarpine rat model, and diminished hippocampal mechanistic target of rapamycin (mTOR) activity, suggesting that 5-HT6Rs may mediate limbic seizures via mTOR signaling (Wang et al., 2015). Here, MTOR is linked to Seizure.