More interestingly, in contrast with elevated level of IL-6, IL-8 and IL-1β detected in BAL of healthy smokers in comparison with nonsmokers, the decreased capacity of smokers’ AM to release IL-1, IL-6, IL-8 and TNF-α has been oberserved in many studies and this decreased secretion of cytokines may result in impairment of pulmonary immune responses in smokers with increased incidence of infection [49–52]. The gene discussed is CXCL8; the disease is infection.