It has been suggested that the MDM2 SNP285C allele might reduce the risk of female cancers (such as breast, ovarian, and endometrial cancer), due to the estrogen receptor (ESR) reported to be as a transcriptional activator with Sp1 [35] and one of the estrogen receptor binding elements (EREs) in the MDM2 P2 promoter overlapped with the Sp1 binding site harboring SNP285 [16]. Here, ESR1 is linked to endometrial cancer.