In particular, we will (I) introduce a general classification of anemic conditions; (II) describe types of anemia induced by RBC dysfunction, including (II.a) defects of Hb chain compositions (defined as hemoglobinopathies) such as SCD and thalassemia; (II.b) defects of cytoskeletal proteins; and (II.c) redox dysregulation and hemolytic anemia. The gene discussed is GSTM1; the disease is thalassemia.