BRCA2 and breast cancer: Based on these filtering criteria, we eliminated six out of eight genes leaving biallelic variants in BRCA2 (MIM: 600185) and REEP6. BRCA2 is a well-characterized tumor suppressor gene, mutations in which are associated with cancers of the breast, brain, pancreas, and prostate; thus, biallelic variants identified in BRCA2 were deemed unlikely to be associated with RP based on biological plausibility.