REEPs and Yop1p are ER-resident proteins that act as membrane-shaping adaptor proteins to regulate ER membrane structure.23, 25, 26, 27, 28 Mutations in REEP1 (MIM: 609139) and REEP2 (MIM: 609347) cause autosomal-dominant hereditary spastic paraplegia (MIM: 610250) and distal hereditary motor neuropathy (MIM: 614751).29, 30, 31 Recent studies have shown that REEP1 is important in neurite development and establishing the structure of the peripheral ER32 and in facilitating ER-mitochondria interactions.33 The gene discussed is REEP2; the disease is distal hereditary motor neuropathy.