In this study, we investigated the effects of niclosamide, analog 11, and analog 32 on ovarian cancer cells and found that niclosamide and its analogs inhibited the Wnt/β-catenin, mTOR, and STAT3 pathways in chemoresistant ovarian cancer cell lines, in cells derived from a chemoresistant ovarian cancer patient-derived xenograft (PDX model), and tumorspheres cultured from cells isolated from the ascites of patients with ovarian cancer. This evidence concerns the gene MTOR and ovarian carcinoma.