More important, according to the univariate analysis data, exosomal CRNDE-h over-expression, local invasion, distant metastasis, regional lymph node metastasis, and CEA high-level were selected and put into the Cox regression multivariate analysis to determine whether exosomal CRNDE-h expression was an independent factor of OS for CRC patients. Here, CEACAM5 is linked to colorectal carcinoma.