In particular, depending on its intracellular localization, B-catenin may play a dual role in epithelial cells: being a plasma membrane component and linking E-cadherin to the actin cytoskeleton, it is essential for adherens junction activity; on the other hand, it is also a major effector of the Wnt pathway and localizes to the nucleus after the loss or downregulation of E-cadherin expression, thus enhancing tumor aggressiveness and metastatic potential. This evidence concerns the gene CDH1 and neoplasm.