Until now, the prognostic values of LFNG, HES1 and PSEN1, and the relationship between their mRNA level with BC DFS have not been evaluated; however, the present study has two key novel findings: firstly, that an elevated level of LFNG, HES1 and PSEN1 has a favorable effect in lumA BC, as predicted, while lowered LFNG, PSEN1 and HES1 expression correlated with better prognosis in TN BC (Figure 2). Here, PSEN1 is linked to breast cancer.