Until now, the prognostic values of LFNG, HES1 and PSEN1, and the relationship between their mRNA level with BC DFS have not been evaluated; however, the present study has two key novel findings: firstly, that an elevated level of LFNG, HES1 and PSEN1 has a favorable effect in lumA BC, as predicted, while lowered LFNG, PSEN1 and HES1 expression correlated with better prognosis in TN BC (Figure 2). This evidence concerns the gene HES1 and breast cancer.