The association between rs430397 in GRP78 and HCC risk is best described by a dominant model (AA+AG vs. GG), (p= 0.0095, OR= 1.81) whereas the association between rs738409 in PNPLA3 is best described by a recessive model (GG vs. CG +CC), (p= 6.28×10-3, OR= 2.56) (Table 5). This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.