CD40LG and B-cell chronic lymphocytic leukemia: Next, to determine differences in the sensitivity to TAK-659 treatment according to the stimuli present in the co-culture system, we cultured primary CLL cells in 4 different conditions: in suspension, stimulated with anti-IgM, co-cultured with BMSC and stimulated with CD40 ligand along with CpG ODN and, co-cultured with the addition of anti-IgM.