We observed that the addition of anti-IgM for 48 hours protected co-cultured CLL cells from undergoing spontaneous apoptosis (Figure 1B) (mean % of viable co-cultured CLL cells related to CLL cells in suspension: 94.08 ± 20.27 without anti-IgM stimulation vs. 137.52 ± 26.17 with anti-IgM stimulation, P < 0.05). The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.