Furthermore, we chose several cardiac hypertrophy-associated genes (i.e. ANF, ACTC1, MYL2, and MYL7) that are upregulated in FC-iPSC-CMs (unpublished data) and examined the efficacy of alpha-galactosidase A (Replagal), IL-18 nAb, or alpha-galactosidase A plus IL-18nAb on the expression of these hypertrophy-associated genes. Here, ACTC1 is linked to cardiac hypertrophy.