We found that, compared with parental cells, CPT-11-resistant CRC cells showed a significant decrease in apoptosis rate, as determined by Annexin V-FITC/PI staining (Figure 3A–3C), whereas inhibition of RhoA by si-RhoA resulted in a significant increase in apoptosis rate in CPT-11-resistant CRC cells (Figure 3A–3C). Here, RHOA is linked to colorectal carcinoma.