RHOA and colorectal carcinoma: Compared with parental cells, the proportion of SP cells were increased significantly in both of the CPT-11-resistant CRC cells (SW620-CPT11,LoVo-CPT11) (p < 0.05, Figure 6A–6C), whereas suppression of RhoA led to a drastic decrease of SP cells in CPT-11-resistant CRC cells (p < 0.05, Figure 6A–6C).