RHOA and colorectal carcinoma: To examine if the increased RhoA expression is important for chemoresistance of CRC, we transfected SW620/CPT-11, LoVo/CPT-11 and parental cells with siRNA targeting RhoA coding sequences (si-RhoA) and control siRNA oligo (si-control), and then examined drug resistance index of the cells to oxaliplatin (L-OHP), cisplatin(DDP), Irinotecan (CPT-11), paclitaxel (PTX), 5-FU, epirubicin (EPI), and Etoposide (VP-16), by in vitro drug sensitivity assay.