Some targets of miR-122 in HCC have been elucidated, including pyruvate kinase M2 (PKM2), cut like homeobox 1 (CUTL1), Ras homolog gene family member A (RhoA), a disintegrin and metalloproteinase domain-containing protein (ADAM)-10 and -17, Cyclin G1, insulin-like growth factor 1 receptor (IGF1R), Bcl-w, Wnt1 and c-Myc, which have been implicated in proliferation, apoptosis and metastasis of HCC cells [108, 116, 118, 119]. Here, PKM is linked to hepatocellular carcinoma.