More importantly, Jie Ding and colleagues have identified the entire miRNA families or clusters that regulate almost all the steps in the NF-κB pathway, among which miR-195, a member of the miR-15 family, plays a crucial role in regulating the TNF-α/NF-κB pathway by down-regulating IκB-α and TAB3 in HCC [146]. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.