More recently, several publications have studied the roles of miR-124 in HCC, and a few targets of miR-124 have been confirmed, such as Rho-kinase 2 (ROCK2), an enhancer of the zeste homologue 2 (EZH2), SET and MYND domain containing 3 (SMYD3), STAT3 and phosphoinositide 3-kinase catalytic subunit α (PIK3CA), through which miR-124 exerts its tumor-suppressive function [123–126]. Here, SMYD3 is linked to hepatocellular carcinoma.