In this study, we investigated the correlations between the progression free survival and patients' gender, age, body mass index, pathology stage, tumor size, lymphatic metastasis, TNM stage, EGFR, COX2, p53, nm23, Combined with EGFR and nm23, and evaluated mainly the possible prognostic and predictive values of p53, COX2, EGFR and nm23. This evidence concerns the gene TP53 and neoplasm.