Hierarchical analysis showed that EGFR expression mainly affects the PFS of pathological grade I-II colorectal cancer patients, the median PFS of pathological grade I-II colorectal cancer patients with EGFR high expression was 28.37 months, the median PFS of pathological grade I-II colorectal cancer patients with low EGFR expression was 65.07 months (χ2=18.766, P<0.001). The gene discussed is EGFR; the disease is colorectal cancer.