NME1 and colorectal cancer: nm23 Expression mainly affects PFS of the pathological grade III-IV colorectal cancer patients, the median PFS was 40.40 months in pathological grade I-II colorectal cancer patients with high nm23 expression, and the median PFS was 35.93 months in pathological grade I-II colorectal cancer patients with low nm23 expression (χ2=1.102, P=0.294).