AKT2 and central nervous system cancer: AKT pathway genes AKT2 and AKT3, which contribute to glioma invasiveness and malignancy (Chautard et al, 2014), and class II myosins, required for glioma invasion and neural stem cell migration (Beadle et al, 2008; Ostrem et al, 2014), were also progressively up‐regulated as one moves along the backbone of the SF10345 phylogeny (Fig 8D).