In Schistosoma haematobium-induced bladder carcinoma, p53 has been connected to aggressive urothelial and squamous cell carcinomas, as well as in non-malignant parasite-infected tissues, suggesting its potential as a diagnostic marker for early detection of Schistosoma-infected patients at risk of developing of bladder cancer [86]. The gene discussed is TP53; the disease is squamous cell carcinoma.