High and moderate expression of EphA5 was observed in 100% (20/20) of normal fallopian tube samples, 100% (24/24) of benign epithelial ovarian tumors, 76% (32/42) of ovarian serous borderline tumors, and 31% (19/61) of ovarian serous carcinomas. This evidence concerns the gene EPHA5 and ovarian serous carcinoma.