TYROBP and Nasu-Hakola disease: Loss of function for either TREM2 or DAP12 has clinical implications, resulting in polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), a rare and fatal disease also known as Nasu Hakola disease, characterized by bones cysts and late-onset dementia [8, 9].