Mice with type 1 diabetes that are susceptible to chronic systemic inflammation and enhanced susceptibility to sepsis showed increased expression of Alox5, which encodes 5-lipoxygenase (5-LOX), and enhanced concentrations of IL-1β in peritoneal macrophages and serum, while treatment with insulin reduced LTB4 concentrations. The gene discussed is ALOX5; the disease is Sepsis.