In this context, it is noteworthy that LXA4 but not its stable analog 15-epi-16-(para-fluorophenoxy)-lipoxin A4 methyl ester (when both were given at a dose of 7 μg/kg, i.v.)in the cecal ligation and puncture (CLP) model of sepsis increased 8 day survival despite the fact that both compounds reduced plasma TNF-α and IL-6 concentrations. The gene discussed is TNF; the disease is Sepsis.