The largest cluster consisted of pathways related to cancer (FALVELLA SMOKERS WITH LUNG CANCER, HEDENFALK BREAST CANCER BRACX UP), cell cycle (INTERPHASE OF MITOTIC CELL CYCLE, INTERPHASE, G1 S TRANSITION OF MITOTIC CELL CYCLE), ERα receptor signaling (WILLIAMS ESR1 TARGETS DN, FRASOR RESPONSE TO ESTRADIOL UP), and angiogenesis (ABE VEGFA TARGETS 2HR, ELVIDGE HIF1A TARGETS DN). The gene discussed is ESR1; the disease is cancer.