The de-regulated expression of CXXC5 is also suggested to correlate with the development, and resistance to therapies, of various pathologies including cardiovascular disease, diminished ovarian reserve (DOR), Blepharophimosis Ptosis Epicantus inversus Syndrome (BPES), Acute Myeloid Leukemia (AML) and breast cancer12, 18, 19, 20, 21, 22, 23. The gene discussed is CXXC5; the disease is cardiovascular disorder.