PRPF3 and retinitis pigmentosa 1: PRPF3 gene is one of pre-mRNA splicing genes and located in the region 150.29–150.33 Mb on chromosome 1q216.Though PRPF3 is essential for splicing and ubiquitously expressed in almost every cell of the body, mutations in the gene have so far been reported to cause a disease that displays retina-specific phenotype RP.