Similar to Hdac1Δ/Δ; Hdac2Δ/Δ, we found that Hdac1Δ/Δ; Hdac2Δ/+ impacted Eμ-myc tumorigenesis by reducing the Eμ-myc-induced blasts at the early preBII cell stage in the BM, resulting in reduced circulating tumor cells (Fig. 5). The gene discussed is MYC; the disease is neoplasm.