Importantly, no Hdac1Δ/Δ; Hdac2Δ/Δ Eμ-myc mice had HG-NHL in spleen and lymph nodes, whereas ablation of either Hdac1 or Hdac2 alone did not prevent HG-NHL development (Fig. 3B, table). This evidence concerns the gene HDAC2 and non-Hodgkin lymphoma.