Given that mutations occurring on KRAS exon 2–4 in colorectal cancer – in addition to those occurring on NRAS exon 2–4 – may play a role in determining resistance to moAb-EGFRs11, these molecular characterizations could also be investigated in SCAC in view of the potential usefulness of these antibodies in this type of cancer. The gene discussed is NRAS; the disease is colorectal cancer.