In this assay, compared with the untransfected Hep G2 (CON) and LV-SH-CON-transfected Hep G2 groups, the MVD in tumor tissue was significantly decreased in the mice of LV-SH-BMP2-transfected Hep G2 group, whereas it was significantly increased in the mice overexpression-LV-BMP2-transfected Hep G2 group (all P < 0.05). Here, BMP2 is linked to neoplasm.